【Main Ingredient】Naproxen

【Properties】This product is a white or off-white tablet.

【Pharmacological Effects】Pharmacodynamics: The inhibitory effect of this product on prostaglandin synthase is 20 times that of aspirin. It has a significant anti-inflammatory effect, as well as analgesic and antipyretic effects. It is effective for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, chronic diseases of the musculoskeletal system (such as joints, muscles and tendons), and mild to moderate pain. Its efficacy is stronger than that of piroxicam.

Pharmacokinetics: The bioavailability of the drug when administered orally is 50%. Food does not affect absorption. The peak blood concentration occurs 2 to 3 hours after administration, and the half-life is 46 hours. It is metabolized in the liver, and the drug can still be detected in the urine 48 hours after administration. The oral administration in dogs results in rapid absorption, and the peak blood concentration occurs 2 to 3 hours after administration.

0.5 to 3 hours, the bioavailability is 68% to 100%, the serum protein binding rate is 99%, the apparent volume of distribution is 0.13L/kg, the elimination half-life reaches 74 hours, and it is caused by intestinal-lymphatic circulation.

【Drug Interactions】 (1) This product can enhance the anticoagulant effect of drugs such as dicoumarol, leading to poisoning and bleeding reactions. The reason is that naproxen can competitively bind to plasma proteins, increasing the proportion of free anticoagulant drugs.

(2) When used in combination with furosemide or hydrochlorothiazide, it can reduce the sodium-reducing diuretic effect of the latter, because this drug not only inhibits the synthesis of prostaglandins in the kidneys, but also inhibits the excretion of diuretics from the renal tubules.

(3) Probenecid can increase the blood concentration of this drug and significantly prolong the plasma half-life of this drug.

(4) Aspirin can accelerate the excretion of this product.

[Function and Application] Antipyretic, analgesic and anti-inflammatory drug. It is used to treat lameness and joint pain caused by myositis and soft tissue inflammation.

【Usage and Dosage】For oral administration: One dose per 10kg body weight. For horses, 0.5 to 1 tablet; for dogs, 0.2 to 0.5 tablet.

【Adverse Reactions】 (1) It can significantly inhibit the migration of white blood cells, and also has an inhibitory effect on platelet adhesion and aggregation, which can prolong the clotting time.

(2) This product has milder side effects compared to aspirin, but it still causes gastrointestinal reactions such as ulcers and even bleeding. Dogs are more sensitive to it, and extremely sensitive dogs may develop nephritis.

(3) It may cause jaundice and angioedema. Long-term use should be accompanied by monitoring of renal function.

【Important Notes】 (1) Dogs are sensitive to this product. Ulcer bleeding or kidney damage may occur. Use with caution.

(2) Not suitable for animals with digestive tract ulcers.

【Drug-free Period】 No need to set.