【Main Component】Enrofloxacin

【Properties】This product is a light white tablet.

【Pharmacological Effects】 Pharmacodynamics  Enrofloxacin belongs to the fluoroquinolone class of drugs specifically for animals. It is a broad-spectrum bactericidal agent. It has good effects on Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella multocida, Pasteurella canis, Proteus, Moraxella, Proteus mirabilis, Streptococcus pyogenes, mycoplasma, chlamydia, etc. Its effect on Pseudomonas aeruginosa and Streptococcus is relatively weak, and its effect on anaerobic bacteria is weak. It has a significant post-antibiotic effect on sensitive bacteria. The mechanism of action of this drug is to inhibit the DNA gyrase of bacteria, interfere with the replication, transcription and repair and recombination of bacterial DNA, and bacteria cannot grow and reproduce normally and die.

Pharmacokinetics  Most animals can absorb this drug well when taken orally. The bioavailability of this drug in dogs is approximately 80%, and it reaches 50% of the peak concentration 15 minutes after oral administration, and reaches the peak within 1 hour. The bioavailability of this drug in chickens is 62.2% - 84%. It is widely distributed in the body and can well enter tissues and body fluids. Except for cerebrospinal fluid, the drug concentration in almost all tissues is higher than that in plasma. The main metabolism in the liver is to remove the 7-piperazine ring's ethyl group to form ciprofloxacin, followed by oxidation and glucuronidation. It is mainly excreted through the kidneys (through renal tubular secretion and glomerular filtration), with 15% - 50% being excreted in its original form from the urine. The elimination half-life of this drug in dogs is 3.7 - 5.8 hours, in cats is 6 hours, and in chickens is 9.1 - 14.2 hours.

【Drug Interactions】 (1) This drug has a synergistic effect when used with aminoglycosides or broad-spectrum penicillins.

(2) Heavy metal ions such as Ca2+, Mg2+, Fe3+, and Al3+ can form chelates with this drug, affecting its absorption.

(3) When used with theophylline, caffeine, etc., it can reduce the plasma protein binding rate, causing abnormal increases in the concentrations of theophylline and caffeine in the blood, and even causing symptoms of theophylline poisoning.

(4) This drug has an inhibitory effect on liver enzymes, reducing the clearance rate of drugs mainly metabolized in the liver and increasing blood drug concentrations.

【Effects and Indications】 Quinolone antibacterial drugs. Used for bacterial diseases and mycoplasma infections.

【Usage and Dosage】 Oral administration: One-time dose, 1 - 1.5 tablets per 1 kg of body weight; for dogs and cats, 0.5 - 1 tablet. Take twice a day, for 3 - 5 days.

【Adverse Reactions】 (1) It causes degeneration of cartilage in young animals, affecting bone development and causing lameness and pain.

(2) Digestive system reactions include vomiting, loss of appetite, diarrhea, etc.

(3) Skin reactions include rash, itching, urticaria, and photosensitivity reactions.

(4) Dogs and cats may experience allergic reactions, ataxia, and epileptic seizures.

【Precautions】 (1) Do not use during the laying period of poultry intended for human consumption.

(2) Urochicken is prohibited.

(3) It has a potential stimulating effect on the central nervous system, inducing epileptic seizures, and should be used with caution in dogs with epilepsy.

(4) Carnivorous animals and animals with poor renal function should use it with caution, and may occasionally develop crystalluria.

(5) This drug is not suitable for dogs under 8 weeks of age.

(6) Drug-resistant strains of this drug are increasing, and it should not be used at subtherapeutic doses for long-term use. 【Withdrawal Period】 8 days for chickens.