【Main Component】Sulfonamidomycin

【Properties】This product is a white or off-white powder.

【Pharmacological Effects】Pharmacodynamics: It belongs to the aminoglycoside class of antibiotics. Its mechanism of action and antibacterial spectrum are similar to those of other aminoglycoside antibiotics. It interferes with the bacterial protein synthesis process, resulting in abnormal protein synthesis and hindering the release of already synthesized proteins. Additionally, it can increase the permeability of the bacterial cell membrane, causing the leakage of some important physiological substances, ultimately leading to bacterial death.

Streptomycin has antibacterial effects against Mycobacterium tuberculosis and various Gram-negative bacteria, such as Escherichia coli, Salmonella, Brucella, Pasteurella, Shigella dysenteriae, and Brucella melitensis. Its effectiveness against most Gram-positive cocci, including Staphylococcus aureus, is poor. Streptococcus, Pseudomonas aeruginosa, and anaerobic bacteria have inherent resistance to this drug.

Pharmacokinetics: Intramuscular injection has good absorption. The peak blood concentration is reached within 0.5 to 2 hours. Under the usual dosage, the effective concentration in the blood can be maintained for 6 to 12 hours. It is mainly distributed in extracellular fluid and can reach the bile, pleural fluid, ascites, tuberculous cavities and caseous tissues, and can also pass through the placental barrier. The concentration is the highest in the kidneys. The levels in the lungs and muscles are relatively low. The concentration in brain tissue is almost undetectable (about 4% of the serum concentration in horses). The protein binding rate is 20% to 30%. This drug is mainly excreted from the kidneys as the original form, with a high concentration in urine. A small amount is excreted from the bile after intramuscular injection. After intramuscular injection, the elimination half-life of streptomycin in horses and water buffaloes is 2.4 to 3.1 hours; in yellow cattle, dairy goats and pigs, it is 3.8 to 4.8 hours.

【Drug Interactions】 (1) When used in combination with other drugs that have nephrotoxicity, ototoxicity and neurotoxicity, such as amphotericin, other aminoglycoside drugs, polymyxin B, etc., do so with caution.

(2) When used in combination with diuretics that act on the loop of the kidney (such as furosemide) or osmotic diuretics (such as mannitol), the ototoxicity and nephrotoxicity of aminoglycoside drugs can be enhanced.

(3) When used in combination with general anesthetics or neuromuscular blocking agents, it can enhance neuromuscular conduction blockage.

(4) When used in combination with penicillins or cephalosporins, it has a synergistic effect against Pseudomonas aeruginosa and Enterococcus, and may have an additive effect on other bacteria.

[Function and Application] Aminoglycoside antibiotics. They are mainly used to treat infections caused by sensitive Gram-negative bacteria and Mycobacterium tuberculosis.

【Usage and Dosage】 Measured in terms of streptomycin. Intramuscular injection: The dosage for each administration is 10-15mg per 1kg of body weight for livestock. Administer twice a day for 2-3 days.

【Adverse Reactions】 (1) Ototoxicity. Streptomycin is the most common cause of vestibular damage. This damage can worsen with the accumulation of the drug over time and is dose-dependent.

(2) Excessive dosage leads to neuromuscular blocking effects.

(3) Long-term use may cause damage to the kidneys.

[Notes] (1) Streptomycin has cross-allergic reactions with other aminoglycoside drugs. It is prohibited for use in animals that are allergic to aminoglycosides.

(2) This drug should be used with caution in cases where the animal shows signs of dehydration (which may lead to an increase in blood drug concentration) or has impaired kidney function.

(3) When using this product to treat urinary tract infections, carnivorous and omnivorous animals can simultaneously take sodium bicarbonate orally to make the urine alkaline, thereby enhancing the efficacy of the medicine.

(4) Cations such as Ce+, Mg2+, Na+, NH4+ and K+ can inhibit the antibacterial activity of this class of drugs.

(5) When used in combination with cephalosporins, dextran, potent diuretics (such as furosemide), erythromycin, etc., it can enhance the ototoxicity of this class of drugs.

(6) Muscle relaxants (such as succinylcholine chloride, etc.) or drugs with such effects can enhance the neuromuscular blocking effect of this type of drugs.

【Withdrawal Period】For cattle, sheep and pigs: 18 days; Milk withdrawal period: 72 hours

【Specification】 (1) 0.75g (750,000 units) (2) 1g (1,000,000 units) (3) 2g (2,000,000 units) (4) 4g (400,000 units)

(100,000 units) (5) 5g (500,000 units)