【 Main Ingredient 】 Erythromycin lactate

【Properties】This product is a white or off-white crystalline substance, or powder, or loose block-like material.

【Pharmacological Effects】Erythromycin lactobionate belongs to the macrolide class of antibacterial drugs. Its effect on Gram-positive bacteria is similar to that of penicillin, but its antibacterial spectrum is broader than that of penicillin. The Gram-positive bacteria that are sensitive to erythromycin include Staphylococcus aureus (including penicillin-resistant Staphylococcus aureus), pneumococcus, streptococcus, Bacillus anthracis, swine erysipelas bacillus, Listeria, Clostridium botulinum, gas gangrene bacillus, etc. The Gram-negative bacteria that are sensitive to erythromycin include Haemophilus influenzae, meningococcus, Brucella, Pasteurella, etc. In addition, erythromycin also has good effects on Campylobacter, mycoplasma, chlamydia, rickettsia and leptospira. It is often used as a substitute drug for animals that are allergic to penicillin. Bacteria can easily develop high-level resistance to erythromycin through chromosomal mutations, and this form of resistance can occur during treatment. The resistance mediated by bacterial plasmids for erythromycin is also relatively common, mainly caused by methylation of the drug target. Cross-resistance between erythromycin and other macrolides and lincomycin is also relatively common.

【Drug Interactions】 (1) Erythromycin should not be used concurrently with other macrolide antibiotics, lincosamides, and chloramphenicol due to the same target sites of action.

(2) When used in combination with beta-lactam antibiotics, it exhibits an antagonistic effect.

(3) When used in combination with penicillin, it has a synergistic inhibitory effect on Rhodococcus equi.

(4) Erythromycin has the effect of inhibiting the cytochrome oxidase system. When used in combination with certain drugs, it may inhibit their metabolism.

【Function and Application】Macrolide antibiotics. They are mainly used to treat infectious diseases caused by penicillin-resistant Staphylococcus, as well as to treat infections caused by other Gram-positive bacteria and mycoplasma.

【Usage and Dosage】In terms of erythromycin. Intravenous injection: The dosage for each administration is 3-5mg per 1kg of body weight for horses, cattle, sheep, and pigs; 5-10mg for dogs and cats. Administer twice a day for 2-3 days.

Before use, dissolve it first with sterile distilled water (do not use sodium chloride injection), and then dilute it with 5% glucose injection. The concentration should not exceed 0.1%.

【Adverse Reactions】When 2-4 month-old horses use erythromycin, they may experience high body temperature and breathing difficulties, which are more likely to occur in hot environments. [Precautions] (1) This product has strong local irritation. Intramuscular injection is not recommended. When the concentration of intravenous injection is too high or the speed is too fast, local pain and thrombotic phlebitis may occur. Therefore, the speed of intravenous injection should be slow.

(2) It will quickly lose its efficacy in solutions with a low pH. The pH of the injected solution should be maintained above 5.5.

【Withdrawal Period】For cattle: 14 days; for sheep: 3 days; for pigs: 7 days; Discontinuation of milk production period: 72 hours.

【Specification】 Measured in erythromycin (1) 0.25g (250,000 units) (2) 0.3g (300,000 units)