【Main Components】 Enrofloxacin

【Properties】 This product is a light white tablet.

【Pharmacological Actions】

Pharmacodynamics: Enrofloxacin belongs to the fluoroquinolone class of broad-spectrum bactericidal drugs for animals. It has a good effect on Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelothrix rhusiopathiae, Proteus, Serratia marcescens, Corynebacterium pyogenes, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. Its effect on Pseudomonas aeruginosa and Streptococcus is relatively weak, and it has a weak effect on anaerobic bacteria. It has a significant post-antibiotic effect on sensitive bacteria. The antibacterial mechanism of this product is to act on bacterial DNA gyrase, interfering with the replication, transcription, and repair and recombination of bacterial DNA, preventing bacteria from growing and reproducing normally and causing their death.

Pharmacokinetics: This product is well absorbed when administered orally to most animals. The bioavailability in dogs is about 80%, and 50% of the peak concentration can be reached within 15 minutes after oral administration, with the peak concentration reached within 1 hour. It is widely distributed in the animal body and can enter tissues and body fluids well. The drug concentration in almost all tissues is higher than that in plasma, except for cerebrospinal fluid. The main metabolic pathway in the liver is the removal of the ethyl group from the 7-piperazine ring to form ciprofloxacin, followed by oxidation and glucuronide conjugation. It is mainly excreted through the kidneys (by tubular secretion and glomerular filtration), with 15% to 50% excreted in the urine in its original form. The half-life of this product when administered orally is 3.7 to 5.8 hours in dogs and 6 hours in cats.

【Drug Interactions】

(1) This product has a synergistic effect when used in combination with aminoglycosides or broad-spectrum penicillins.

(2) Heavy metal ions such as Ca2+, Mg2+, Fe3+, and Al3+ can chelate with this product, affecting absorption.

(3) When used in combination with theophylline or caffeine, it can reduce the plasma protein binding rate, causing abnormal increases in the concentrations of theophylline and caffeine in the blood, and even leading to theophylline poisoning symptoms.

(4) This product has an inhibitory effect on liver enzymes, which can reduce the clearance rate of drugs mainly metabolized in the liver, increasing their blood concentrations.

【Functions and Uses】 Fluoroquinolone antibacterial drug. It is used for bacterial diseases and mycoplasma infections in animals.

【Dosage and Administration】 Calculated as enrofloxacin. Oral administration: 2.5 to 5 mg per 1 kg body weight, once a day, for 3 to 5 days, or as directed by a veterinarian.

【Adverse Reactions】

(1) It can cause degeneration of cartilage in young animals, affecting bone development and causing lameness and pain.

(2) Gastrointestinal reactions include vomiting, loss of appetite, and diarrhea.

(3) Skin reactions include redness, itching, urticaria, and photosensitivity reactions.

(4) Occasionally, allergic reactions, ataxia, and epileptic seizures may occur in dogs and cats.

【Precautions】

(1) It has a potential excitatory effect on the central nervous system and can induce epileptic seizures. Dogs with epilepsy should use it with caution.

(2) It should be used with caution in animals with poor kidney function, as it may cause crystalluria.

(3) Intramuscular injection may cause transient irritation.

(4) This product is not suitable for cats under 8 weeks of age, small dogs under 12 months of age, and large dogs under 18 months of age.

(5) The number of drug-resistant strains is increasing, and it should not be used at sub-therapeutic doses for a long time. 

【Withdrawal Period】 None required.

【Specifications】 (1) 2.5mg  (2) 5mg